Abstracts & Posters

International Severe Asthma Registry (ISAR): protocol for a global registry
Price D, et al. 2019; 17314.

Describes ISAR’s creation, governance and data collection protocol. To date, > 25 countries (Americas, Europe, Asia/Pacific, Middle East) contribute or are planning to contribute to ISAR.

Epidemiology of lung function in a global severe asthma population
Wechsler M, et al. 2019; 20215.

Describes the post-bronchodilator lung function of adult severe asthma patients for an initial set of 5 countries participating in ISAR using a standardized severe asthma definition. Results showed that fixed airway obstruction is evident in severe asthma, with poor bronchodilator responsiveness noted, irrespective of smoking history or treatment on GINA Step 4 or 5.

Protocol to identify potential severe asthma in UK primary care
Heatley H, et al. 2019; 18381.

Identifies potential severe asthma patients in UK primary care. Future analyses will compare these data with ISAR data.


Overlap of biomarkers and T2 comorbidities in an international severe asthma population
Bulathsinhala L, et al. 2019; 09.

A description of key patient characteristics and biomarker clusters in a sample of the ISAR database, a first taste of how ISAR could be used to identify specific phenotypes of severe asthma.


International Severe Asthma Registry (ISAR): the story so far
Price D, et al.; on behalf of the ISAR Study Group. 2019; 13145.

A description of ISAR’s continued expansion and what it adds to the severe asthma field.

Cross-country comparison of demographic and clinical characteristics of patients managed in severe asthma services across UK, USA, Australia, South Korea and Italy
Price D, et al.; on behalf of the ISAR Study Group. 2019; 12959.

First characterization of the global adult severe asthma population (and cross country comparisons) in terms of key demographic and clinical variables.


International Severe Asthma Registry (ISAR): mission statement
Canonica W and Price D, on behalf of the ISAR Study Group. 2019; 82.

Describing the potential of ISAR to improve our understanding of severe asthma.

Comparison of data fields captured by regional severe asthma registries participating in the International Severe Asthma Registry (ISAR)
Eleangovan N, et al. 2019; 1514.

Comparing data fields captured by national registries pre- and post-participation in ISAR. ISAR and local registries complement each other, the former providing a global view of severe asthma and the latter collecting ISAR core-, additional- and registry-specific-variables most relevant to local clinical management.

International Severe Asthma Registry: a real-life data capture model
Bulathsinhala L, et al. 2018; P19. [Poster]

A description of how ISAR was created, how data are collected and the countries involved.

Published Articles

Development of the International Severe Asthma Registry (ISAR): a modified Delphi study
Bulathsinhala L, et al. J Allergy Clin Immunol Pract 2019; 7(2): 578-588.e2.
[PubMed] [Full Text]

Getting 27 experts to agree on anything is impressive! This paper describes the process of reaching consensus on which core variables to collect in ISAR.

Press releases

Development of the International Severe Asthma Registry (ISAR): a modified Delphi study

This press release highlights the first ISAR publication published in the Journal of Allergy and Clinical Immunology: In Practice


September 2018

Find out more about ISAR, take a look at first results from the registry and learn more about our planned publications, academic projects, and other news. Please feel free to share this newsletter with your colleagues.