Asthma Phenotyping in Primary Care: Applying the International Severe Asthma Registry Eosinophil Phenotype Algorithm Across All Asthma Severities.
In this study, the International Severe Asthma Registry (ISAR) eosinophil phenotype gradient algorithm was applied to a UK primary care cohort that included patients from the Optimum Patient Care Research Database (OPCRD) and the Clinical Practice Research Datalink. The eosinophilic phenotype was predominant across all asthma severities in UK primary care; 72.5% of patients had most likely or likely eosinophilic phenotypes and 5.6% of patients were non-eosinophilic. Patients with most likely eosinophilic asthma tended to have more comorbidities, poorer asthma control and greater healthcare resource utilization than those with non-eosinophilic asthma. Asthma eosinophilic phenotyping should become part of routine clinical practice in primary care, since patients with eosinophilic asthma phenotypes may benefit from Type 2 targeted treatments such as inhaled corticosteroids and biologics.
Link to publication: https://lnkd.in/eX6WEhs5
Link to slide set: https://lnkd.in/g4Dvc5m
Link to CHEST editorial on the ISAR eosinophil phenotype gradient algorithm: https://lnkd.in/eDUgC7Ws
Link to September 2021 CHEST podcast on the ISAR eosinophil phenotype gradient algorithm: https://lnkd.in/ekHUxdEj
ISAR: www.isaregistries.org
OPCRD: www.opcrd.co.uk
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