Dissemination of ISAR SUNNIE

Biologics for severe asthma: time to switch it up?

Ever wondered about the pattern of use of biologics in real-life? Or whether the first biologic prescribed to a patient is the best one for that individual? This study explored these questions and more, using data from both ISAR and CHRONICLE and found, quite surprisingly, that even in a world with multiple biologic choices for severe asthma only about 11% of patients switched from one biologic to another and even a smaller proportion (10%) stopped. Interestingly if a change to biologic therapy was made, the pattern of switch vs ditch was country dependent. Some countries like the US, UK and Spain leaned towards stopping, while others like Kuwait, Bulgaria, Canada, Denmark, South Korea, Italy and Greece were more likely to switch. So, are we getting it right from the get-go, or are we under-switching?

Check out this figure to see the most common biologic switch patterns. 

Link to full article: https://lnkd.in/g2KRYG6E
Link to summary slide set: https://lnkd.in/g7ENk4sr
You can also see a summary of ISAR research: https://lnkd.in/g7ENk4sr

#severe asthma #ISAR #biologics #healthcare

Pattern of biologic switch (n=377)
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Impact of Socioeconomic Status on Adult Patients with Asthma: A Population-based Cohort Study from UK Primary Care.

Impact of Socioeconomic Status on Adult Patients with Asthma: A Population-based Cohort Study from UK Primary Care.

In this study, we investigated the effects of socioeconomic status (SES) on clinical outcomes in a UK primary care asthma cohort (N=127,040) from the Optimum Patient Care Research Database (OPCRD). There was evidence of socioeconomic disparities, which had adverse effects on asthma outcomes.

Patients from the most deprived quintile were more likely to have decreased peak flow, uncontrolled asthma or an exacerbation during follow-up than those from the least deprived quintile, yet their rates of respiratory referrals remained comparable. This should raise clinical awareness that more deprived patients may have greater need for specialist reviews and phenotype-targeted treatments like biologics. This study also demonstrated that the magnitude of the impact of SES on asthma outcomes was greater in patients who were older or from ethnic minority groups. Interventions to resolve socioeconomic disparities should be explored, both in the UK and globally, to improve overall asthma outcomes.

Link to article: https://lnkd.in/eiyWtgXX
Link to slide set: https://lnkd.in/g4Dvc5m
Link to ISAR research summary slide set: https://lnkd.in/g4Dvc5m
Link to ISAR: www.isaregistries.org
Link to OPCRD: www.opcrd.co.uk

#healthcare #primarycare #OPCRD #socioeconomic #asthma